Search on: PLASMINOGEN INACTIVATORS 
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Descriptor English:   Plasminogen Inactivators 
Descriptor Spanish:   Inactivadores Plasminogénicos 
Descriptor Portuguese:   Inativadores de Plasminogênio 
Synonyms English:   Plasminogen Activator Inhibitors  
Tree Number:   D12.776.872.695
Definition English:   Important modulators of the activity of plasminogen activators. Four inhibitors, all belonging to the serpin family of proteins, have been implicated in plasminogen activation inhibition. They are PAI-1; PAI-2; protease-nexin; and PROTEIN C INHIBITOR; (PAI-3). All inhibit both the tissue-type and urokinase-type plasminogen activators. 
Indexing Annotation English:   serpins; DF: PLASMINOGEN INACT
Pharmacological Action:   Serine Proteinase Inhibitors
 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
CT contraindications DF deficiency
DU diagnostic use EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
SE secretion ST standards
SD supply & distribution TU therapeutic use
TO toxicity UR urine
Record Number:   24836 
Unique Identifier:   D015849 

Occurrence in VHL: 		 

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