Definition English:
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A family of transmembrane glycoproteins that contain a short cytoplasmic domain, a single-span transmembrane domain, and an extracellular domain with HEPARIN SULFATE and CHONDROITIN SULFATE chains. Syndecans interact with a variety of heparin-binding INTERCELLULAR SIGNALING PROTEINS AND PEPTIDES and may play a role in modulating cellular signaling in during EMBRYONIC DEVELOPMENT, tumorigenesis, and angiogenesis. |