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APOPTOSIS
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DeCS
Descriptor
English
:
Apoptosis
Descriptor
Spanish
:
Apoptosis
Descriptor
Portuguese
:
Apoptose
Tree Number:
G04.299.139.160
Definition
English
:
One of the mechanisms by which
CELL DEATH
occurs (compare with
NECROSIS
and AUTOPHAGOCYTOSIS).
Apoptosis
is the mechanism responsible for the physiological deletion of
cells
and appears to be intrinsically programmed. It is characterized by distinctive morphologic changes in the nucleus and
cytoplasm
,
chromatin
cleavage at regularly spaced sites, and the endonucleolytic cleavage of genomic
DNA
; (DNA FRAGMENTATION); at internucleosomal sites. This mode of
cell death
serves as a balance to
mitosis
in regulating the size of animal
tissues
and in mediating
pathologic processes
associated with tumor
growth.
Indexing Annotation
English
:
do not confuse with
NECROSIS
, pathological
cell death
; unspecified probably goes here; PROGRAMMED
CELL DEATH
, TYPE II see
AUTOPHAGY
is also available
See Related
English
:
CARD Signaling Adaptor Proteins
Caspases
Cellular Apoptosis Susceptibility Protein
Death Domain Receptor Signaling Adaptor Proteins
Genes, Transgenic, Suicide
In Situ Nick-End Labeling
Necrosis
History Note
English
:
93
Allowable Qualifiers
English
:
DE
drug effects
GE
genetics
IM
immunology
PH
physiology
RE
radiation effects
Record Number:
30827
Unique Identifier:
D017209
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
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